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Indoor and Built Environment, Vol. 1, No. 5, 268-271 (1992)
DOI: 10.1177/1420326X9200100503

Risk Factors of Development of Delayed Encephalopathy following Acute Carbon Monoxide Poisoning

Fengsheng He

Institute of Occupational Medicine, Chinese Academy of Preventive Medicine

Jie Qin

Institute of Occupational Medicine, Chinese Academy of Preventive Medicine

Shuyang Chen

Institute of Occupational Medicine, Chinese Academy of Preventive Medicine

Xiaowen Pan

Navy Hospital, Beijing, China

Guanghua Xu

Navy Hospital, Beijing, China

Shoulin Zhang

Institute of Occupational Medicine, Chinese Academy of Preventive Medicine

Guangcai Fang

Navy Hospital, Beijing, China

Delayed encephalopathy (DE) is a poorly predictable outcome following acute carbon monoxide (CO) poisoning. In order to define the risk factors of DE in patients with acute CO poisoning and improve prevention, 207 cases of acute CO poisoning were observed during the acute stage and followed up for 3 months: 27 (13%) developed DE. Statistical analyses of 97 factors present in the acute stage showed 6 to be statistically significant risk factors for the devel opment of DE. These were: age > 40 years, occupation involved mental work, previous hypertension, coma at the acute stage lasting 2-3 days, longer persis tence of dizziness and fatigue after regaining consciousness, and being men tally stimulated during the recovery stage of acute CO poisoning. Based on these six factors, a logistic regression equation for predicting the probability of DE in individual patients with acute CO poisoning has been established.

Key Words: Acute poisoning • Carbon monoxide • Delayed encephalopathy • Prediction of probability • Risk factors


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