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Indoor and Built Environment
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Development of a Method for Measuring Volatile Organic Compounds in the Blood of Fire Victims Using'Purge and Trap' Gas Chromatography

Paul Houeto

Toxicology Laboratory, Hôpital Fernand Widal, Unitox, Montréal, Québec, Canada

Stephen W. Borron

INSERM U 26, Paris, International Toxicology Consultants, LLC, Washington, D.C., USA

Fabrice Marlière

Institut National de l'Environnement lndustriel et des Risques (INERIS), Verneuil-en-Halatte, France

Frédéric J. Baud

INSERM U 26, Paris

Pierre Levillain

Toxicology Laboratory, Hôpital Fernand Widal

Smoke inhalation remains a major cause of morbidity and mortality. Clinical and laboratory studies have re vealed numerous potentially toxic components of com bustion in the fire environment and in human tissue samples. However, the frequency and importance of the various compounds remains poorly understood. A new simple method to quantitatively measure volatile or ganic compounds (VOCs) in small samples of the blood of fire victims has been developed utilising the 'purge and trap' method of gas phase chromatography with flame ionisation detection using two columns. Thirty- three compounds were identified on the basis of the retention index method with acceptable repeatability and reproducibility. This method should permit a more complete investigation of the toxic volatile organic com pounds found in fire victims.

Key Words: Volatile organic compounds • Gas chromatography • Smoke inhalation • Combustion products • Acute poisoning

Indoor and Built Environment, Vol. 10, No. 2, 62-69 (2001)
DOI: 10.1177/1420326X0101000202
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