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Indoor and Built Environment, Vol. 11, No. 3, 171-177 (2002)
DOI: 10.1177/1420326X0201100307

Coalinga Fibre: A Short-Fibre, Amphibole-Free Chrysotile

Part 4: Further Evidence for a Lack of Fibrogenic and Tumorigenic Activity

E.B. Iigren

Bryn Mawr, Pa., USA

Coalinga chrysotile is a short-fibre, amphibole-free as bestos from California. It is prototypic of many other short-fibre chrysotiles found elsewhere in the world. Since short-fibre chrysotile is the most common form of asbestos, a deeper understanding of the biological ef fects of Coalinga chrysotile should provide important insights into what many regulatory agencies are now calling a major health hazard, the reasoning behind this being that these agencies consider all fibre types to be biologically equivalent. Previously the potential fibroge nicity of Coalinga chrysotile had been assessed in two inhalation bioassays. The first was conducted in 1978 at the National Institutes of Environmental Health and Sciences (NIEHS) in the United States. Our earlier analy sis of this investigation demonstrated that Coalinga chry sotile was not fibrogenic. The second inhalation bioas say was conducted in 1983 at the Fraunhofer Institute in Germany by Muhle et al. Unfortunately, in their final analysis, data were presented in a way that did not allow one to determine whether Coalinga chrysotile was fi brogenic or not. Because of this, the slides have been re-examined using the Wagner scoring system, which is designed specifically to assess fibrosis. The findings of this re-evaluation clearly demonstrate, yet again, that Coalinga chrysotile is not fibrogenic in these assays.

Key Words: Short-fibre chrysotile • Coalinga • Fibrosis • Neoplasia


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