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Indoor and Built Environment
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Gas Chromatographic Determination of Halothane Levels in Hospital Operating Theatres

Monica Culea

Mass Spectrometry Laboratory, National Institute for Research and Development on Isotopic and Molecular Technology, 135 Donath str., RO 3400 Cluj-Napoca, Roumania,

Simona Nicoarã

Physics Department, Technical University of Cluj-Napoca, 15 C. Daicoviciu str., RO 3400 Cluj-Napoca, Roumania,

Nicoleta-Alina Nica

Mass Spectrometry Laboratory, National Institute for Research and Development on Isotopic and Molecular Technology, 135 Donath str., RO 3400 Cluj-Napoca, Roumania,

Carmen Gherman

Babes-Bolyai University of Cluj-Napoca, 1 Kogalniceanu str., RO 3400 Cluj-Napoca, Roumania

A simple, rapid, and sensitive method for the analysis of halothane in the air of operating theatres has been developed. The procedure involves the pre-concentration of halothane on active charcoal in an adsorption tube, then desorption in toluene, followed by capillary gas chromatography (GC) analysis using a flame ionisation detector (FID). The recovery from air samples after pre-concentration was 67%. The linearity was established with standards over a concentration range between 0 and 3 µL mL–1 of halothane in toluene with an excellent coefficient of correlation (0.99) and a limit of detection of 1 µL halothane per cubic metre of air. The time for analysis was approximately 10 min with an adsorption step of 60-90 min per sample collected on site. The procedure was used for occupational exposure assessment, by quantitation of halothane in two different hospital operating theatres, during a single general anaesthesia for a routine orthopaedic surgery and for a routine internal surgery, respectively.

Key Words: Gas chromatography • Anaesthetics • Halothane • Active charcoal • Operating theatres

Indoor and Built Environment, Vol. 12, No. 1-2, 125-129 (2003)
DOI: 10.1177/1420326X03012001020
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