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Indoor and Built Environment
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Exposure Assessment of Nicotine and Cotinine by GC-MS

Monica Culea

Babes-Bolyai University, Kogalniceanu str. No. 1, 3400 Cluj-Napoca, Romania, mculea{at}phys.ubbcluj.ro

Onuc Cozar

Babes-Bolyai University, Kogalniceanu str. No. 1, 3400 Cluj-Napoca, Romania

Simona Nicoara

Technical University of Cluj-Napoca, Romania

Razvan Podea

Babes-Bolyai University, Kogalniceanu str. No. 1, 3400 Cluj-Napoca, Romania

Environmental tobacco smoke exposure of human subjects in different public houses was evaluated. The levels of airborne nicotine from environmental tobacco smoke and changes in urinary cotinine and nicotine levels between smoking and non-smoking subjects were compared. A gas chromatography-mass spectrometric (GC-MS) quantitative method for nicotine and cotinine levels in the indoor air and in urine was developed. A Thermo Quest Trace DSQ GC-MS equipped with a Rtx-5MS capillary column, 15m 0.25mm, 0.25 m film thickness, was used in a temperature programme starting from 50°C, for 2min, then increased at 8°C·min-1 to 250°C and held for 10min. The method was validated and gave good linearity, precision, accuracy and limit of detection. A significant correlation between urinary cotinine increase and airborne nicotine is presented.

Key Words: Nicotine • Cotinine • GC-MS • Urine • ETS

Indoor and Built Environment, Vol. 14, No. 3-4, 293-299 (2005)
DOI: 10.1177/1420326X05054296
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