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Indoor and Built Environment, Vol. 14, No. 6, 537-541 (2005)
DOI: 10.1177/1420326X04059282

Different Molecular Mechanisms for the Eight Types of Human Lung Cancers

Wayne E. Criss

Biochemistry and Oncology Department, Hacettepe University Medical School, Ankara, Turkey

The various types of lung cancer each have unique properties and their cells show specific changes in molecular regulatory control mechanisms. Each type has mutations/amplifications/over expression of several oncogenes, mutations or loss of cancer suppressor genes, increased telomerase activity and loss of chromosome 3p. These molecular genotypic changes are discussed with regard to the unique phenotypic characteristics of human lung cancers.

Key Words: Lung cancers • ras • myc • src • fos/jun • bcl-2 • p16/INK4A • Rb (Retinoblastoma) • p53 • Telomerase • Chromosome 3p


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